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Ochratoxin A in Milk, Serum, and Urine

Cat. No. 991OCH01MS-96

Overview:

Molds such as Aspergillus and Penicillium, produce ochratoxin A (OTA) in various foods such as grapes, grains, coffee beans, etc. Climates with more humidity, rainfall and hotter temperatures yield crops with higher amounts of OTA. Although, the EU does not have a maximum allowable OTA value for human milk and serum, Ochratoxin A has been shown to be teratogenic, nephrotoxinic, carcinogenic, and an immunosuppressive agent.(1) It has also been linked to Balkan endemic nephropathy which is a type of kidney disease that is common in the rural areas of Yugoslavia and Bulgaria.(1) Testing serum or human milk can be practical to evaluate internal ochratoxin exposure from eating habits.(2) It is suspected that humans have a widespread exposure to this toxin because of its long elimination half-life and widespread existence in human food and animal feed. From constant ingestion of foods contaminated with OTA, the toxins can build up in the body and can pass through the placenta to the fetus. It is suspected that a fetus could be more venerable to OTA's risk factors than adults.(1) OTA is also commonly found in human milk and could pose a serious threat to newborns.(3)

REFERENCES
(1)Skaug MA, Stormer FC, Saugstad OD, Ochratoxin A: A Naturally Occurring Mycotoxin Found in Human Milk Samples from Norway. Acta Paediat 1998; 87: 1275-1278.

(2) Munoz K, et. al., Biomonitoring of Ochratoxin A and its Metabolite Ochratoxin Alpha in Urine, Plasma and Human Milk. Toxicology Letters 2009; 189: 151.

(3)Biasucci G, et al., The Presence of Ochratoxin in Cord Serum and in Human Milk and Its Correspondence with Maternal Dietary Habits. European Journal of Nutrition 2011; 50: 211-218.

(4)Skaug MA, Helland I, Solvoll K, Saugstad OD, Presence of Ochratoxin A in Human Milk in Relation to Dietary Intake. Food Additives and Contaminants 2001; 18: 321-327.

New ELISA Assay for Ochratoxin A

In response, at Helica Biosystems, Inc., we have developed a simple, user-friendly ELISA-based test. This simple, sensitive, and valuable ELISA is suitable for the quantitative measurement of ochratoxin A in human milk, serum and urine.

 

 

 
 
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